Where
Unfortunately, I am not at liberty to mention the specific places we have worked. However it’s been at many major Pharma, Biotech, Research Institutes, NIH Institutes, Government Agencies, Startups, and Academic Labs. Ask Bill about the time he worked at the FBI.
What
Informatics, custom software development, automated workflows on-prem or in any cloud, perform scientific research in genetics and genomics. Ask Bill about the time he installed and configured a cluster live on stage (from an iPod) while delivering a talk on clustered computing.
How
Listen, perform background research, evaluate potential solutions, devise and deploy solutions, transfer knowledge to put ourselves out of work.
Why
We are deeply passionate about science. We have personal connections to rare and age-releated diseases. Honestly, it’s also because it’s really fun.
Publications
Van Etten, W., and G.R. Janssen. An AUG initiation codon, not codon-anticodon complementarity, is required for the translation of unleadered mRNA in Escherichia coli. Molecular Microbiology; March, 1998. PMID: 9535088.
Steen RG, Kwitek-Black AE, Glenn C, Gullings-Handley J, Van Etten W, Atkinson OS, Appel D, Twigger S, Muir M, Mull T, Granados M, Kissebah M, Russo K, Crane R, Popp M, Peden M, Matise T, Brown DM, Lu J, Kingsmore S, Tonellato PJ, Rozen S, Slonim D, Young P, Jacob HJ. A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. Genome Research; June, 1999. PMID: 10400928.
Van Etten, W., et al. Radiation Map of the Mouse Genome. Nature Genetics; August, 1999. PMID: 10431245. Altshuler, D., V. Pollara, C. Cowles, W. Van Etten, J. Baldwin, L. Linton, E. Lander. Construction of a dense SNP map of the Human genome by reduced representation shotgun sequencing. Nature, September, 2000. PMID: 11029002.
Gilman, B., S. Schaffner, W. Van Etten, D Reich, J. Higgins, M. Daly, B. Blumenstiel, J. Baldwin, N. Stange-Thomann, M. Zody, L. Linton, E. Lander, D. Altshuler. A sequence variation map of the human genome containing 1.4 million SNPs. Nature, February, 2001. PMID: 11237013.
Thomas J. Hudson1,2, Deanna M. Church3, Simon Greenaway4, Huy Nguyen1, April Cook1, Robert G. Steen1, William J. Van Etten1, Saulius Girnius1, Mark A. Strivens4, Pamela Trickett4. Christine Heuston4, Claire Davison4, Anne Southwell4, Rachel Hardisty4, Anabel Varela-Carver4, Andrew R. Haynes4, Patricia Rodriguez-Tome5, Hirofumi Doi6, Minoru S.H. Ko7, Joan Pontius3, Lynn Schriml3, Lukas Wagner3, Donna Maglott3, Steve D.M. Brown4, Eric S. Lander11,8, Greg Schuler3, Paul Denny. A radiation hybrid map of mouse genes. Nature Genetics; October, 2001. PMID: 11586302.
Krishna KM, Van Etten WJ 3rd, Janssen GR. Proximity of the start codon to a leaderless mRNA’s 5’ terminus is a strong positive determinant of ribosome binding and expression in Escherichia coli. J Bacteriol. 2010 Dec;192(24):6482-5. PMID: 20971908.
C Yuen RK, Merico D, Bookman M, L Howe J, Thiruvahindrapuram B, Patel RV, Whitney J, Deflaux N, Bingham J, Wang Z, Pellecchia G, Buchanan JA, Walker S, Marshall CR, Uddin M, Zarrei M, Deneault E, D’Abate L, Chan AJ, Koyanagi S, Paton T, Pereira SL, Hoang N, Engchuan W, Higginbotham EJ, Ho K, Lamoureux S, Li W, MacDonald JR, Nalpathamkalam T, Sung WW, Tsoi FJ, Wei J, Xu L, Tasse AM, Kirby E, Van Etten W, Twigger S, Roberts W, Drmic I, Jilderda S, Modi BM, Kellam B, Szego M, Cytrynbaum C, Weksberg R, Zwaigenbaum L, Woodbury-Smith M, Brian J, Senman L, Iaboni A, Doyle-Thomas K, Thompson A, Chrysler C, Leef J, Savion-Lemieux T, Smith IM, Liu X, Nicolson R, Seifer V, Fedele A, Cook EH, Dager S, Estes A, Gallagher L, Malow BA, Parr JR, Spence SJ, Vorstman J, Frey BJ, Robinson JT, Strug LJ, Fernandez BA, Elsabbagh M, Carter MT, Hallmayer J, Knoppers BM, Anagnostou E, Szatmari P, Ring RH, Glazer D, Pletcher MT, Scherer SW. Whole genome sequencing resource identifies 18 new candidate genes for autism spectrum disorder. Nat Neurosci. 2017 Apr;20(4):602-611. PMID: 28263302.